WEB-based GEne SeT AnaLysis Toolkit
 
Translating gene lists into biological insights...
 


User data and parameters: User data: textAreaUpload.txt, Organism: hsapiens, Id Type: ensembl_gene_stable_id, Ref Set: entrezgene, Significance Level: Top10, Statistics Test: Hypergeometric, MTC: BH, Minimum: 2

The results for each enriched gene sets are listed in this table.
For each gene set, the first row lists database name, gene set name , and corresponding gene set ID.
The second row lists the following statistics:
Finally, genes in the pathway are listed. For each gene, the table lists the user uploaded ID and value (optional), Entrez ID, Ensembl Gene Stable ID, Gene symbol, and description. Ensembl Gene Stable ID and Entrez Gene ID are linked to the Ensembl and Entrez Gene databases, respectively.

Database:KEGG pathway       Name:Chagas disease (American trypanosomiasis)       ID:05142
C=104; O=4; E=0.19; R=21.00; rawP=4.17e-05; adjP=0.0013
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000156052 NA GNAQ guanine nucleotide binding protein (G protein), q polypeptide 2776 ENSG00000156052
2  ENSG00000106799 NA TGFBR1 transforming growth factor, beta receptor 1 7046 ENSG00000106799
3  ENSG00000136869 NA TLR4 toll-like receptor 4 7099 ENSG00000136869
4  ENSG00000117020 NA AKT3 v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma) 10000 ENSG00000117020


Database:KEGG pathway       Name:Toll-like receptor signaling pathway       ID:04620
C=102; O=2; E=0.19; R=10.70; rawP=0.0152; adjP=0.0240
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000136869 NA TLR4 toll-like receptor 4 7099 ENSG00000136869
2  ENSG00000117020 NA AKT3 v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma) 10000 ENSG00000117020


Database:KEGG pathway       Name:Salivary secretion       ID:04970
C=89; O=2; E=0.16; R=12.27; rawP=0.0117; adjP=0.0240
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000156052 NA GNAQ guanine nucleotide binding protein (G protein), q polypeptide 2776 ENSG00000156052
2  ENSG00000070961 NA ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 490 ENSG00000070961


Database:KEGG pathway       Name:Peroxisome       ID:04146
C=79; O=2; E=0.14; R=13.82; rawP=0.0093; adjP=0.0240
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000142655 NA PEX14 peroxisomal biogenesis factor 14 5195 ENSG00000142655
2  ENSG00000101473 NA ACOT8 acyl-CoA thioesterase 8 10005 ENSG00000101473


Database:KEGG pathway       Name:TGF-beta signaling pathway       ID:04350
C=84; O=2; E=0.15; R=13.00; rawP=0.0105; adjP=0.0240
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000106799 NA TGFBR1 transforming growth factor, beta receptor 1 7046 ENSG00000106799
2  ENSG00000108854 NA SMURF2 SMAD specific E3 ubiquitin protein ligase 2 64750 ENSG00000108854


Database:KEGG pathway       Name:Endocytosis       ID:04144
C=201; O=3; E=0.37; R=8.15; rawP=0.0061; adjP=0.0240
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000106799 NA TGFBR1 transforming growth factor, beta receptor 1 7046 ENSG00000106799
2  ENSG00000114331 NA ACAP2 ArfGAP with coiled-coil, ankyrin repeat and PH domains 2 23527 ENSG00000114331
3  ENSG00000108854 NA SMURF2 SMAD specific E3 ubiquitin protein ligase 2 64750 ENSG00000108854


Database:KEGG pathway       Name:Apoptosis       ID:04210
C=87; O=2; E=0.16; R=12.55; rawP=0.0112; adjP=0.0240
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000120868 NA APAF1 apoptotic peptidase activating factor 1 317 ENSG00000120868
2  ENSG00000117020 NA AKT3 v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma) 10000 ENSG00000117020


Database:KEGG pathway       Name:Chronic myeloid leukemia       ID:05220
C=73; O=2; E=0.13; R=14.96; rawP=0.0080; adjP=0.0240
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000106799 NA TGFBR1 transforming growth factor, beta receptor 1 7046 ENSG00000106799
2  ENSG00000117020 NA AKT3 v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma) 10000 ENSG00000117020


Database:KEGG pathway       Name:Rheumatoid arthritis       ID:05323
C=91; O=2; E=0.17; R=12.00; rawP=0.0122; adjP=0.0240
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000136869 NA TLR4 toll-like receptor 4 7099 ENSG00000136869
2  ENSG00000114573 NA ATP6V1A ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A 523 ENSG00000114573


Database:KEGG pathway       Name:Pancreatic cancer       ID:05212
C=70; O=2; E=0.13; R=15.60; rawP=0.0074; adjP=0.0240
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000106799 NA TGFBR1 transforming growth factor, beta receptor 1 7046 ENSG00000106799
2  ENSG00000117020 NA AKT3 v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma) 10000 ENSG00000117020




WebGestalt is currently developed and maintained by Jing Wang and Bing Zhang at the Zhang Lab. Other people who have made significant contribution to the project include Dexter Duncan, Stefan Kirov, Zhiao Shi, and Jay Snoddy.

Funding credits: NIH/NIAAA (U01 AA016662, U01 AA013512); NIH/NIDA (P01 DA015027); NIH/NIMH (P50 MH078028, P50 MH096972); NIH/NCI (U24 CA159988); NIH/NIGMS (R01 GM088822).